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[[Cell Structure and Function]]
Type of passive diffusion that allows molecules that can't cross the hydrophobic core on their own using channel or transport proteins. Requires no energy.
# Summary
* Aquaporins are channel proteins that move large quantities of water across the membrane.
* Facilitated diffusion uses transport and channel proteins to move molecules that can't cross the hydrophobic core on their own across the membrane. (More info in Membrane Transport)
* Movement of ions across membrane can polarize it, creating an uneven charge distribution
**How molecular structure decides the route:**
- Small and nonpolar: passes directly through the bilayer.
- Large and polar (like glucose): needs a transport protein.
- Charged ion (like Na⁺ or K⁺): needs a channel protein.
Water can cross the membrane on their own but it's slow, aquaporins transport large quantities.
| Transport Type | Energy Required? | Direction | Examples |
| --------------------- | ---------------- | ----------- | --------------------------------------- |
| Simple Diffusion | No | High to Low | O₂, CO₂ |
| Facilitated Diffusion | No | High to Low | Glucose, ions, water through aquaporins |
| Active Transport | Yes (ATP) | Low to High | Na⁺/K⁺ pump, calcium pumps |
Key difference between simple and facilitated is the protein.